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吸烟可永久改变基因 会导致DNA突变
Having sequenced thousands of tumor genomes, they found a 20-a-day smoker would rack up an average of 150 mutations in every lung cell each year.在对数千个肿瘤基因组进行测序后,科学家发现每天吸烟20支的人每年每个肺细胞累积平均有150个基因突变。
The changes are permanent, and persist even if someone gives up smoking.这些突变是永久且持续的,即使吸烟者戒烟也不可逆。
The analysis shows a direct link between the number of cigarettes smoked in a lifetime and the number of mutations in tumor DNA.研究显示,人一生中吸烟的总数量和肿瘤DNA变异的数量之间存在直接关系。
The authors found that, on average, smoking a packet of cigarettes a day led to:研究作者发现,平均来讲,每天吸一包烟会导致:
150 mutations in each lung cell every year每年每个肺部细胞中有150个基因突变。
97 in the larynx or voice box喉部或喉头97个突变
23 in the mouth口腔部位23个突变
18 in the bladder膀胱18个突变
6 in the liver肝脏6个突变
Joint lead author Prof Sir Mike Stratton, from the Wellcome Trust Sanger Institute,said:"The more mutations there are, the higher the chancethat these will occur
in the key genes that we call cancer genes, which convert a normal cell into a cancer cell. "
研究报告的合作主创者、来自基金会桑格研究院的迈克-斯特拉顿教授说:“突变越多,关键基因,也就是我们所说的癌症基因发生突变的几率也就越大,这会将正常细胞转变为癌细胞。”点击“阅读原文”